NSAID Side Effects: What You Need to Know Before Taking Them

When you reach for ibuprofen or naproxen to ease a headache or sore back, you’re using a type of medication called NSAIDs, nonsteroidal anti-inflammatory drugs that reduce pain, fever, and inflammation. Also known as nonsteroidal anti-inflammatories, they’re one of the most common drug classes in the world—but they’re not harmless, even when bought without a prescription. Many people think because NSAIDs are available over the counter, they’re safe to use anytime. That’s not true. These drugs can cause real harm, especially if you take them often, in high doses, or with other medications.

One of the biggest risks is damage to your stomach and intestines. Gastrointestinal risks, including ulcers, bleeding, and perforation are well-documented. You might not feel anything until it’s too late. People over 65, those on blood thinners, or anyone with a history of stomach issues are at higher risk. Even short-term use can trigger problems if you’re sensitive. Then there’s the kidney damage from NSAIDs, a silent threat that can develop without symptoms until kidney function drops. Your kidneys filter these drugs, and over time, regular use can reduce blood flow to them—especially if you’re dehydrated or already have kidney disease. It’s not rare. Studies show NSAID-related kidney injury is one of the top causes of acute kidney problems in older adults.

NSAIDs also interact dangerously with other common meds. For example, if you’re taking lithium for bipolar disorder, even a small dose of ibuprofen can spike lithium levels in your blood to toxic ranges. The same goes for diuretics and some blood pressure drugs. These interactions aren’t always listed on the bottle. And while you might think a few pills a week won’t hurt, the truth is: chronic use—even at low doses—adds up. Many people don’t realize they’re taking NSAIDs daily because they’re in combination products like cold medicines or migraine formulas.

What you’ll find in the articles below isn’t just a list of side effects. It’s real-world insight from people who’ve dealt with these issues, and the science behind why they happen. You’ll learn how to spot early warning signs, how to talk to your pharmacist about safer alternatives, and what to do if you’ve been taking NSAIDs for years without knowing the risks. Some posts even explain how to reduce harm if you still need them—like timing your doses or pairing them with protective strategies. This isn’t about scare tactics. It’s about giving you the facts so you can make smarter choices with the meds you’re already using.