Wegovy vs Xenical: A Clear Comparison of Two Popular Weight‑Loss Drugs

When you see Wegovy vs Xenical, a side‑by‑side look at two FDA‑approved medications for obesity management. Also known as weight‑loss drug showdown, it helps you decide which option fits your health goals.

The two drugs aren’t interchangeable. Wegovy contains semaglutide, a GLP‑1 receptor agonist that mimics a gut hormone to curb appetite. Xenical’s active ingredient is orlistat, a lipase inhibitor that blocks about a third of dietary fat from being absorbed. Both target obesity, but they attack the problem from opposite ends—one reduces hunger, the other reduces calories that actually make it into your bloodstream.

How They Work, How Well They Work

Think of semaglutide as a brain‑signal manager. It binds to GLP‑1 receptors in the hypothalamus, slowing gastric emptying and telling your body you’re full sooner. Clinical trials show an average 15 %‑20 % body‑weight loss after a year of weekly injections. Orlistat, by contrast, stays in the gut. It binds to pancreatic lipases, preventing them from breaking down triglycerides. Users typically see a 3 %‑5 % weight drop when paired with a reduced‑fat diet.

Side‑effects also follow the mechanisms. Wegovy often brings nausea, vomiting, or mild diarrhea—signs your gut is adjusting to slower emptying. Xenical’s most common complaints are oily stools, urgent bowel movements, and occasional flatulence, especially if you eat a high‑fat meal. These effects are predictable and can be mitigated: low‑fat meals for Xenical, gradual dose escalation for Wegovy.

Cost is a major factor. Wegovy’s brand‑name price in the U.S. hovers around $1,300 per month, though insurance may cover part of it for patients with a BMI ≥ 30 kg/m² or ≥ 27 kg/m² with comorbidities. Xenical is a generic drug, typically $30‑$70 for a month’s supply, making it far more accessible for many. However, efficacy differences mean some patients consider the higher expense worthwhile for the larger weight loss.

Patient suitability also shapes the decision. Wegovy is ideal for individuals seeking a substantial weight‑loss result and who can handle injections and possible GI upset. It’s not recommended for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2. Xenical works best for those who prefer oral therapy, have moderate weight‑loss goals, and can commit to a lower‑fat diet. It’s not suitable for people with chronic malabsorption syndromes or cholestasis.

Wegovy vs Xenical isn’t just a headline—it's a decision tree that starts with your health profile, budget, and lifestyle preferences. Below you’ll find a curated set of articles that dive deeper into each drug’s dosing schedule, real‑world patient experiences, insurance navigation tips, and how they compare to other obesity treatments like bariatric surgery or newer GLP‑1 agents. Use this guide to match the right tool to your weight‑loss journey and make an informed choice.