Prochlorperazine — what it does, when to use it, and what to watch for
Prochlorperazine (brand name Compazine) is an older but still common drug used mainly for nausea, vomiting, and severe hiccups. Doctors also used it for psychosis in the past, but today it’s most often a rescue medicine for bad nausea from migraines, chemotherapy, or post-surgery. It works by blocking dopamine in the brain, which calms the vomiting center but also causes some of the drug’s side effects.
How prochlorperazine works and common uses
Think of prochlorperazine as a fast-acting anti-nausea option. It comes as tablets, a liquid, rectal suppositories, and injections. For nausea, adults commonly take 5–10 mg by mouth every 6–8 hours as needed; injections may be used in the ER for quicker relief. For psychiatric uses, doses are higher and carefully monitored by a specialist. Always follow the exact dose your provider gives you—don’t mix dosing instructions from different sources.
Use cases you’ll see most: sudden severe nausea from migraine or chemotherapy, post-op nausea, and stubborn hiccups that don’t stop with home remedies. If you have long-term nausea, your provider may choose a different drug with fewer long-term risks.
Side effects, warnings, and safe use
Side effects are the main reason this drug needs careful use. Common ones are drowsiness, dry mouth, blurred vision, and low blood pressure when you stand up. More serious effects include extrapyramidal symptoms—like muscle restlessness, tremors, or stiff movements—and tardive dyskinesia, which can be long-lasting. There’s also a rare but life-threatening reaction called neuroleptic malignant syndrome (very high fever, stiff muscles, confusion). If you notice sudden muscle problems, high fever, odd movements, or severe drowsiness, get medical help right away.
Prochlorperazine can be risky for older adults, people with Parkinson’s disease, those with severe heart problems, or anyone with a history of low white blood cell counts. It can interact with other drugs that sedate you (like opioids, benzodiazepines, or alcohol) and with medicines that affect the heart rhythm. Tell your provider about all medicines and supplements you take.
Pregnancy and breastfeeding need a quick chat with your clinician. Some providers avoid strong antipsychotics in pregnancy unless benefits clearly outweigh risks. Don’t stop or start prochlorperazine without checking with your healthcare team.
Want to buy this medication online? You should only use licensed pharmacies and always keep a valid prescription. Cheap or sketchy sites may sell counterfeit pills that are dangerous. If you’re unsure, ask your pharmacist or doctor for trusted sources and consider using a pharmacy verification tool.
Bottom line: prochlorperazine can stop severe nausea fast, but it has real side effects that need respect. Use the lowest effective dose, watch for movement problems or severe drowsiness, and stay in touch with your healthcare provider if anything feels off.
The Stigma Surrounding Prochlorperazine Use: Breaking Down Barriers
As a blogger, I'm passionate about raising awareness on important issues like the stigma surrounding prochlorperazine use. In recent years, I've noticed that many people feel embarrassed or ashamed to discuss their use of this medication, which is primarily prescribed for nausea and dizziness. Through my writing, I hope to break down these barriers and encourage open conversations surrounding prochlorperazine use. By addressing misconceptions and sharing personal stories, we can create a more supportive environment for those who rely on this medication. Together, we can work towards eliminating the stigma and ensuring everyone gets the care they need.
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